Publications

Harding, C. M.; Nasr, M. A.; Scott, N. E.; Goyette-Desjardins, G.; Nothaft, H.; Mayer, A. E.; Chavez, S. M.; Huynh, J. P.; Kinsella, R. L.; Szymanski, C. M.; Stallings, C. L.; Segura, M.; Feldman, M. F., A platform for glycoengineering a polyvalent pneumococcal bioconjugate vaccine using E. coli as a host. Nat Commun 2019, 10 (1), 891.

Harding, C. M.; Feldman, M. F., Glycoengineering bioconjugate vaccines, therapeutics, and diagnostics in E. coli. Glycobiology 2019, 29 (7), 519-529.

Feldman, M. F.; Mayer Bridwell, A. E.; Scott, N. E.; Vinogradov, E.; McKee, S. R.; Chavez, S. M.; Twentyman, J.; Stallings, C. L.; Rosen, D. A.; Harding, C. M., A promising bioconjugate vaccine against hypervirulent Klebsiella pneumoniae. Proc Natl Acad Sci U S A 2019, 116 (37), 18655-18663.

Knoot, C. J.; Robinson, L. S.; Harding, C. M., A minimal sequon sufficient for O-linked glycosylation by the versatile oligosaccharyltransferase PglS. Glycobiology 2021, 31 (9), 1192-1203.

Duke, J. A.; Paschall, A. V.; Robinson, L. S.; Knoot, C. J.; Vinogradov, E.; Scott, N. E.; Feldman, M. F.; Avci, F. Y.; Harding, C. M., Development and Immunogenicity of a Prototype Multivalent Group B Streptococcus Bioconjugate Vaccine. ACS Infect Dis 2021, 7 (11), 3111-3123.

Christine Szymanski, Ph.D.

Co-Founder

Dr. Szymanski is a Professor at the Complex Carbohydrate Research Center and Associate Department Head of Microbiology at the University of Georgia. She has been exploring bacterial glycomics for three decades. She combines her expertise in food safety and animal health with novel therapeutic diagnostic platforms developed during her postdoctoral fellowship at the Naval Medical Research Center vaccine program, the key findings while employed at the National Research Council of Canada, and the translational advances during her tenure as an Alberta Innovates Technology Futures Scholar at the University of Alberta where she cofounded VaxAlta, a company creating glycoconjugate vaccines for livestock and human health applications.

Dr. Szymanski has published over 100 publications and has served as President of the Society for Glycobiology and President of the Canadian Society of Microbiologists. She is a Fellow of the American Academy of Microbiology and has received the Peter Gallagher Memorial Glycomics Award for Contributions to Health and Medical Research.

Steven Projan, Ph.D.

Scientific Advisory Board Member

Dr. Projan is the former Senior Vice President and Head of Infectious Diseases & Vaccines Innovative Medicines at MedImmune. He had previously served as VP and Global Head of Infectious Diseases at Novartis and VP and Head of Biological Technologies at Wyeth. Dr. Projan is an expert in infectious diseases, having worked many years with both basic and applied research, successfully led four programs resulting in the approval of novel anti-infective drugs and produced more than 110 peer-reviewed publications. He is currently Principal in his consulting company Beat the Reaper, LLC.

Dr Projan received his Ph.D. in Molecular Genetics from Columbia University under Jim Wechsler and a BS from MIT. He was a postdoctoral fellow at the Public Health Research Institute, where he studied plasmid replication, antibiotic resistance, and staphylococcal virulence in collaboration with Richard Novick.

Viliam Pavliak, Ph.D.

Scientific Advisory Board Member

Viliam (Vilo) Pavliak, PhD is an expert in a vaccine development with over 28 years of experience in the industrial, academic and non-for-profit vaccine R&D for developed and emerging markets. He provides strategic direction, tactical oversight, and technical expertise to vaccine development activities at Gates MRI consisting of analytical and formulation development, Drug Substance & Drug Product process development, scale-up, tech transfer, pre-clinical and clinical manufacturing, and commercial scale development. Before that, he was Head of Vaccine Development at International Vaccine Institute (IVI) in Seoul, South Korea, where he led process and assay development activities and technology transfers to developing country manufacturers. Prior to IVI, Dr. Pavliak spent 17 years at Wyeth/Pfizer where he directed vaccine characterization work and the development of analytical assays for release of conjugate vaccines and intermediates for vaccine programs, including Prevenar®, Staphylococcus aureus 4-Antigen (SA4Ag) Vaccine, Neisseria meningitidis LOS based conjugate vaccine and Group B Streptococcus Polysaccharide Conjugate Vaccine. Prior to Wyeth, Dr. Pavliak led preclinical development and evaluation of vaccines against several Gram-positive pathogenic bacteria at Nabi and Univax Biologics Inc.

Dr. Pavliak did his postdoctoral research with Dr. Neil Glaudemans at the NIH/NIDDK, Bethesda, Maryland, USA and Dr. Harold Jennings at the Institute of Biological Sciences, NRC, Ottawa, Canada. He received his MS and PhD in Biochemistry from the Slovak Technical University, Bratislava, Slovakia. He also serves as a member of the Scientific Advisory Board of GlycoNet (Canadian Glycomics Network, Alberta, Canada).

Mario Feldman, Ph.D.

Co-Founder & Scientific Advisory Board Member

Mario F. Feldman is a Professor of Molecular Microbiology in the Department of Molecular Microbiology at Washington University School of Medicine, in St Louis. He graduated with a B.S. in Biotechnology from the National University of Rosario, Argentina and received a Ph.D. from the University of Buenos Aires, Argentina. He then held postdoctoral positions at the University of Basel and the Swiss Federal Institute of Technology (ETH), Zurich, Switzerland. Before joining Washington University, he was an Associate Professor at the University of Alberta, Canada, where he cofounded VaxAlta, a spin-off company dedicated to livestock vaccines. Dr. Feldman’s current research focuses on the pathogenesis of the multi-drug resistant bacterium Acinetobacter baumannii. He is recognized for his work characterizing secretion systems, microbial glycans, and outer membrane vesicles. He has coauthored over 80 publications in prestigious journals and he has been awarded with multiple NIH grants.

Dr. Feldman is a Fellow of the American Academy of Microbiology. He received the Canadian Institute of Health New Investigator Award.

Roman Fleck, Ph.D., MBA

Chairperson

Dr. Fleck is the CEO of Janpix, which was recently merged into Centessa Pharmaceutical. He was previously a Venture Partner/Advisor to Medicxi after having been a Principal at Index Ventures Life Sciences, Medicxi’s predecessor company. He invested in and represented Index Ventures on the boards of GlycoVaxyn (sold to GSK), Versartis (NASDQ: VSAS), and Novocure (NASDQ: NVCR). Earlier at Index Ventures he was also involved with Funxional Therapeutics (sold to Boehringer Ingelheim) and Micromet (sold to Amgen). He started his career at Boehringer Ingelheim Pharmaceuticals in Connecticut where he led drug development projects in oncology, inflammation and cardiovascular disease, advancing several compounds from pre-clinical to clinical stage.

Dr. Fleck received a Ph.D. in bioorganic chemistry from MIT as well as an MBA from NYU’s Stern School of Business. He has authored or co-authored numerous publications in prestigious journals as well as many issued patents.

Timothy Cooke, Ph.D., MBA

Chief Executive Officer

Dr. Cooke has over thirty years of experience in the biopharmaceutical industry with a focus on vaccines. He was previously CEO of NovaDigm Therapeutics, CEO of Mojave Therapeutics, COO at AVANT Immunotherapeutics, and SVP at Ology Bioservices. Prior to his leadership roles in the biotechnology industry, he held several positions at Merck establishing a global vaccine-focused marketing and sales organization.

Dr. Cooke has been the Biotechnology Industry Representative to the U.S. National Vaccine Advisory Committee since 2015. He is on the Advisory Board of Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator (CARB-X) and is an observer on the WHO Technical Advisory Group on Vaccines and Antimicrobial Resistance. He was previously Co-Chair of the BIO Vaccine Policy Advisory Committee and was on the Incentives for Vaccines Working Group of the Presidential Advisory Council on Combating Antibiotic-Resistant Bacteria. Dr. Cooke was the Vaccine Industry Representative to the Working Group of Gavi, the Vaccine Alliance during its formation in 2000.

Dr. Cooke has a Ph.D. in bio-organic chemistry and an M.B.A. from Columbia University and a B.S. from Saint Joseph’s University.

Christian Harding, Ph.D.

Chief Scientific Officer & Co-Founder

Dr. Harding is the primary innovator and driver behind Omniose’s R&D activity and bioconjugation platform development. For more than five years, Dr. Harding has helped refine Omniose’s bioconjugation platform for use in developing bioconjugate vaccines against different bacterial threats. He has been awarded multiple federally funded SBIR and STTR grants, authored numerous peer-reviewed manuscripts in distinguished journals, and is the inventor of multiple issued Omniose patents.

Dr. Harding conducted his Postdoctoral Fellowship under Dr. Mario Feldman’s mentorship at Washington University in St. Louis focusing on microbial glycobiology. He earned his Ph.D. in Biomedical Sciences from The Ohio State University and a B.S. from the College of Charleston in Charleston, South Carolina.